The Generation R study is a large population based prospective cohort study from early pregnancy onwards until adulthood in the city of Rotterdam in the Netherlands.
The study is designed to identify early environmental and genetic causes and pathways leading to normal and abnormal growth, development and health during fetal life, childhood and adulthood. Specific interest is in the effects of fetal and early childhood conditions on health and disease in later life. One of the many main outcomes in the Generation R study are new or well known risk factors in childhood and adulthood for cardiovascular diseases. This study is the first to examine the association of vascular-related pregnancy disorders with maternal and childhood vascular and cardiac function, using novel and unique techniques, in a large prospective cohort design.
The measurements will form a basis for further follow-up studies in which risk factors of cardiovascular disease will be studied.